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WHAT IS SEMAGLUTIDE?
Semaglutide is FDA approved, a once-weekly injection, for chronic weight management in adults
when used in combination with a healthy diet and exercise.
The medication had made headlines before its approval when the manufacturer
reported 15% to 18% weight loss findings during clinical trials.
This is higher than we tend to see with other weight loss medications.
Since then, semaglutide has also been approved for chronic weight management in
adolescents ages 12 and older.
Semaglutide improves body composition by reducing excess body fat, including abdominal fat,
and increasing the proportion of lean body mass, or the amount of weight someone carries that
is not body fat. The more body weight a participant lost, the greater the improvement in
While semaglutide doesn't provide immediate weight loss, it works quickly.
A study published in The New England Journal of Medicine showed that after just four weeks
of taking semaglutide, patients experienced more than a 2% reduction in body weight.
BENEFITS OF SEMAGLUTIDE
• LOSE THE WEIGHT
• FDA APPROVED FOR WEIGHT LOSS
• CURB YOUR APPETITE
• LOWER YOUR BLOOD PRESSURE
FREQUENTLY ASKED QUESTIONS
What is Semaglutide? Semaglutide is an injectable medication that, when combined with diet and exercise, helps with blood sugar control in Type II diabetics. Semaglutide belongs to a class of medications called glucagon-like peptide-1 (GLP-1) agonists, which mimic the hormone GLP-1 in your body to lower blood sugar levels after eating.
How does Semaglutide work for Weight Loss? GLP-1 agonists like Semaglutide work to control your blood sugar, and peoples who take Semaglutide also tend to lose weight. GLP-1, the critical hormone involved, slows down how fast your stomach empties food. In addition to causing your pancreas to release insulin, Semaglutide also blocks a hormone in your liver to release glucagon. Together, these mechanisms can help you feel less hungry, causing you to eat less food and lose more weight.
How long does it take to lose weight on Semaglutide? With Semaglutide, you will slowly work your way up to the target dose when you see the most weight loss. This was the case in clinical trials, where participants had their dose adjusted until they reached 2.5 mg if needed. In the phase 3 trial that measured outcomes at 20 weeks, most participants were able to reach the full dose and also lost weight as their dose was increased. They saw an additional weight loss over the remaining 48 weeks at the full dose. It is important to remember that weight loss can take time, and you will see the best results when using Semaglutide in combination with a healthy diet and exercise. Sometimes the medication may not work for you, or you may not be able to tolerate the full dose due to side effects.
What is the starting dose of Semaglutide for weight loss? All participants start on the lowest dose of Semaglutide at 0.25 mg, injected subcutaneously into the belly fat weekly. All patients will increase by 0.25mg every two weeks as tolerated. The dosing being studied for weight loss is 2.5mg once weekly, which is higher than the dose approved for diabetes. Semaglutide is being studied in different populations: people with a BMI greater than 30% or 27% with at least one weight-related comorbidity.
Is Semaglutide a stimulant? No, Semaglutide is not a stimulant. While other weight loss medications like phentermine have stimulating effects that help curb your appetite, Semaglutide works differently.
Does my insurance cover Semaglutide? No. Semaglutide is not covered by insurance for people who are not Type II Diabetic. However, you can get Semaglutide prescribed as part of the Semaglutide weight loss program.
What is the hormone GLP-1? GLP-1 is a hormone that causes huge effects on the regulation of blood sugar by stimulating glucose-dependent insulin secretion. Insulin is a hormone that promotes sugar uptake by the cells, stores sugar as glycogen, promotes the building of fat, and signals the body to build skeletal muscle. In addition, GLP-1 inhibits glucagon release, which slows down the release of sugar into the blood so that you will burn more fat, slows down gastric emptying, so you feel full longer, and lowers the desire to eat.
Does Semaglutide curb your appetite? Yes! It is believed that Semaglutide helps curb your appetite. In addition to slowing gastric emptying to make you feel full longer. GLP-1 also plays a direct role in how appetite is regulated.
How long should you take Semaglutide for weight loss? Currently, Semaglutide is only approved for obesity and to help with blood sugar control in type 2 diabetics and to lower the risk of major cardiovascular events in people with type 2 diabetes and heart disease. If you are taking Semaglutide. In studies, participants received Semaglutide for 68 weeks (about 1.5 years) during each of the four trials conducted by the company.
Is Semaglutide a type of Insulin? No, Semaglutide is not a type of insulin or a substitute for insulin. Semaglutide stimulates your pancreas to release your insulin when glucose (sugar) is present because Semaglutide relies upon your body’s own insulin to have this effect; Semaglutide isn’t used when your pancreas can’t make insulin, such as in patients with Type 1 diabetes.
Is Semaglutide safe? Yes. Semaglutide is considered safe and effective when used as indicated. However, being safe does not mean there are no risks. Semaglutide carries a boxed warning about thyroid C-cell tumors occurring in rodents with unknown risks in humans. Semaglutide should not be used if you or your family has a history of certain thyroid cancers. Semaglutide should not be used in people with Type 1 diabetes or a history of pancreatitis. Semaglutide should be used cautiously for people on other blood sugar-lowering medications.
Is Semaglutide approved by the FDA? Yes.
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